Heme-Dependent and Independent Soluble Guanylate Cyclase Activators and Vasodilation
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منابع مشابه
Heme deficiency of soluble guanylate cyclase induces gastroparesis.
BACKGROUND Soluble guanylate cyclase (sGC) is the principal target of nitric oxide (NO) to control gastrointestinal motility. The consequence on nitrergic signaling and gut motility of inducing a heme-free status of sGC, as induced by oxidative stress, was investigated. METHODS sGCβ1 (H105F) knock-in (apo-sGC) mice, which express heme-free sGC that has basal activity, but cannot be stimulated...
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Nitric oxide (NO) is an essential vasodilator. In vascular diseases, oxidative stress attenuates NO signaling by both chemical scavenging of free NO and oxidation and downregulation of its major intracellular receptor, the alphabeta heterodimeric heme-containing soluble guanylate cyclase (sGC). Oxidation can also induce loss of the heme of sGC, as well as the responsiveness of sGC to NO. sGC ac...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Pharmacology
سال: 2010
ISSN: 0160-2446
DOI: 10.1097/fjc.0b013e3181eb4e75